Joint Replacement

Rated 3.3 out of 5
Based on 31 reviews

15g amino acids

10g protein

50 calories

For preventing muscle weakness after joint surgery†
Orange Mango
Are you preparing for Joint Replacement Surgery?
When is your surgery date?
  • Joint Replacement
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  • Joint Replacement

“My research with Dr. Hans Dreyer on perioperative EAA supplementation in TKA continues to advance and it’s exciting to see the evidence continue to grow.”

Dr. Erin Owen

VP Clinical Research Mend

"The #1 question I get from my patients is what can I do to enhance my recovery from joint replacement surgery. I tell them Mend.”

Dr Paul Jacob, DO

Orthopedic Surgeon

Oklahoma Joint Reconstruction Institute

How to Take Joint Replacement

  • gluten-free

  • non-gmo



  • made in the usa

ingredients researched and proven to prevent muscle atrophy and weakness

clinical nutrition designed for optimal recovery

  • + L-Isoleucine
    An essential branched-chain amino acid that promotes protein synthesis & glucose uptake
  • + L-Valine
    Amino acid that works with isoleucine & leucine to promote growth, repair tissue & provide muscle energy
  • + L-Histidine
    Amino acid obtained from dietary sources; a proteinogenic amino acids, helping to synthesize proteins
  • + L-Phenylalanine
    Amino acid that must be obtained from dietary sources & serves as a building block for various proteins
  • + L-Methionine
    A dietary essential amino acid that plays unique roles, both in protein structure & metabolism
  • + L-Leucine
    The branched-chain amino acid most beneficial in stimulating synthesis for muscle tissue building
  • + L-Lysine
    An amino acid that is used in the biosynthesis of proteins. Important in supplying energy to muscles
  • + L-Tryptophan
    An essential amino acid that helps the body to make proteins and certain brain signaling chemicals
  • + L-Threonine
    Supports synthesis of glycine and serine to assist in production of collagen, elastin and muscle tissue

Joint Replacement is a trusted formula backed by science and research.

clinically researched ingredients

+ EAA Supplementation Mitigates Muscle Atrophy

Essential Amino Acid supplementation reduces the loss of muscle volume in older adults recovering from total knee arthroplasty.

MEND Study with Slocum
Learn More
+ EAA Supplementation Associated with Improved TKA Recovery

Supplementation of amino acids prior to and for 2 weeks after surgery improves patient recovery.

Learn More
+ EAA Supplementation following TKA

Essential Amino Acid treatment reduces muscle atrophy and accelerates return to functional mobility following TKA.

MEND Study with Slocum
Learn More
+ The Cellular Basis of Muscle Atrophy Reduction

EAAs pre-surgery increases satellite cells at the time of surgery and promotes a more favorable inflammatory environment post-surgery.

MEND Study with Slocum
Learn More
+ EAAs May Enhance The Hip Functional Retrieval

Patients significantly improved their levels of glycine, alanine, tyrosine, and total amino acids. In addition, they enhanced the rate of hip function recovery.

Learn More
+ EAAs Improve Circulating Albumin & Haemoglobin

Following hip fractures, EAAs improves hypoAlb and, to a lesser extent, Hb. Anaemia was reduced in more than one third of patients & may be clinically relevant.

Learn More


Why do I need Joint Replacement? How will it benefit me?

Joint replacement surgery has become extremely advanced and with the latest technologies and techniques you’re on your way to a life changing procedure that will give you back quality of life. To enhance your recovery, ensure you are increasing your caloric intake to give your body the fuel it needs during recovery. Also add Joint Replacement to your diet to give your muscles a targeted blend of essential amino acids to preserve muscle tissue and preserve strength. The clinical studies are clear, with mend in your system, your recovery will be enhanced.†

Who developed Joint Replacement, is it manufactured in the US?

Joint Replacement was developed by MEND Nutrition Inc., a U.S. corporation that is focused on developing evidence based medical nutrition products. All of our products are manufactured 100% in the U.S. utilizing U.S. sourced ingredients with labs that meet the highest standards in manufacturing. We are proud to have won a number awards and become recognized for innovative high quality products. We now count as clients numerous MDs, professional sports teams, US Military and other high caliber discerning clients.

Is Joint Replacement proven to work?

There have been three double blind placebo controlled randomized clinical trials demonstrating that this formulation is effective. We are currently conducting a fourth double blind placebo controlled trial as we believe the increase in leucine in our formula will further enhance outcomes.
In short, yes the science shows that taking this formula will prevent muscle loss and enhance your recovery from joint replacement surgery. Learn more about our science here.†

Does Joint Replacement require a prescription?

Joint Replacement is dietary supplement and does not require a prescription.

Is Joint Replacement covered by insurance?

Joint Replacement is not currently covered by insurance but we are actively looking into this.

How is Joint Replacement taken?

Joint Replacement is a powder mixed with water, juice, your favorite smoothie or added to food like yogurt. For optimal taste and maximum absorption of nutrients we recommend blending into a smoothie. There are a number of smoothie recipes provided on our website.  Watch our instructional video on how to take Joint Replacement.†

Is Joint Replacement safe to be taken before surgery?

Joint Replacement contains only well-studied, well-tolerated nutrients that are safe and may be taken before and after surgery. It is always advisable to check with your doctor before taking any dietary supplements. If your surgeon is unaware of Joint Replacement, please contact us ( for a brochure that you can print and take to his/her office. Your surgeon will be interested in the clinical studies, which can be found in the Clinical Research section of this site and which we are happy to email to you for easy sharing with your surgeon.†

When should I take Joint Replacement?

Clinical studies show that you should ideally start taking Joint Replacement at least 1 week prior to surgery and continue for 6 weeks post surgery. Benefits have been seen in as little as 2 weeks post surgery. For maximum long-term results, we recommend taking Joint Replacement during this acute phase and switching to Regenerate for on-going nutritional support.

How much should I take?

It is recommended to take 1 scoops per serving, 2 times per day.

How many servings in a bottle? How long does it last?

There are 21 servings per bottle. Two bottles are needed for the recommended minimum 3 week course (1 week prior to surgery and 2 weeks post).

Can I take Joint Replacement for ongoing use after surgery?

It is not advised to take Joint Replacement for longer than our recommended period as there have been no studies performed on long-term use. If you’re looking for a product to take daily after your recovery to preserve or add lean muscle mass and for general wellness, we would recommend our award winning product MEND Regenerate (learn more at†

What is the flavor, what does it taste like?

The flavor is Orange Mango. We chose this flavor to mask some of the bitter profile of amino acids, which are difficult to mask. We believe you’ll enjoy the taste even with water alone and certainly when mixed with juice or blended with a smoothie. For convenience many clients just add it to juice.

Where can I buy Joint Replacement?

Joint Replacement is available through doctors or surgeons or can be purchased directly from our website.

Can you ship to my country?

Yes, Joint Replacement is shipped worldwide. Please be aware of your country’s policy for importing dietary supplements and that additional taxes and tariffs may be applied by your country. In most cases it is delivered without a problem but sometimes customs can hold and ask you to pick up or call to arrange for delivery.

Are there any side effects?

The essential amino acids in Joint Replacement are safe and there are no contraindications or harmful side effects. Occasionally people with sensitive stomachs may experience some initial gas or slight irritability. This should subside as your stomach adjusts to the amino acids. If you do experience any irritation, you can simply dilute with additional juice or water, this usually resolves the issue.

Joint Replacement Reviews

average rating 3.3 out of 5
Based on 31 reviews
  • 5 Stars
    11 Reviews
  • 4 Stars
    6 Reviews
  • 3 Stars
    3 Reviews
  • 2 Stars
    2 Reviews
  • 1 Star
    9 Reviews
61% of reviewers would recommend this product to a friend
31 Reviews
Reviewed by MARK C.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Mark Conner

Surgery went great, utilized your product throughout, hard to judge the impact of the product since I have nothing to compare it to. However, when I have my other knee replaced I will be using your product, because I don't want to find out if there is a difference. I choose to believe my excellent outcome was in part because of your product.

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Reviewed by Sharon R.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Good Stuff!

I think it works very well. I am healing nicely! It tastes okay mixed with orange juice. Just don't mix the powder with banana in a smoothie - I thought that combination wasn't tasty at all.


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Reviewed by Deborah R.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Faster healing

I think taking this every day has helped me heal faster. I only had my knee surgery a month ago and I am seeing much progress since I started using this replacement.

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Reviewed by ALEX B.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted



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Reviewed by Ellen B.
Verified Reviewer
I recommend this product
Rated 5 out of 5
Review posted

Satisfied with Mend Orthopedic

I am very pleased with this Mend product, drinking it before and after my hip revision surgery. The best cold drink for me to put it in is Lemonade. It masks the taste and smell well. I highly recommend!

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