MEND Regenerate is a complete daily formula with 34 nutrients to support muscle health, performance and well-being. Improve muscle health, combative oxidative stress, support a healthy gut and reduce low level inflammation.†
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INGREDIENTS & BENEFITS
- Our protein complex contains both whey protein isolate and concentrate which are both rapidly absorbed combined with casein which requires several hours to be digested.
- Since whey rapidly increases protein synthesis and casein blocks protein breakdown, a combination of both is considered to be ideal.
- For maximum absorption, and to support healthy digestion, we have included whey protein isolate in combination with whey protein concentrate to reduce the amount of lactose, fat and carbohydrates while providing the high quality protein needed support aging muscle.
- Casein provides a prolonged plateau of amino acid concentration in blood plasma lasting over 7 hours. The result is a sustained release of amino acids into the blood stream.
Data supports the ability of dietary protein to acutely stimulate muscle protein synthesis in aging individuals and that moderately increasing daily protein intake beyond the recommended daily allowance may enhance muscle protein anabolism and provide a means of reducing the progressive loss of muscle mass with age.
A study published in The Journal of Nutrition demonstrates the benefits of consuming a protein blend for muscle protein synthesis after exercise. The correct blend of proteins can provide complementary amino acid profiles and different digestion rates (amino acid release profiles). The result provides fast absorption combined with a prolonged delivery of amino acids to muscles and extended muscle protein synthesis when subjects consumed a blend when compared to a single source of protein alone.
- Leucine, isoleucine, and valine are the three branched-chain amino acids (BCAAs) that are highly effective for stimulating skeletal muscle protein synthesis.
- BCAAs are required for protein synthesis necessary for muscle growth, in addition to helping to support healing of injured tissues and the healthy functioning of the nervous system.
- BCAAs have been shown to be the major carriers of amino nitrogen between the viscera and the peripheral tissues, including skeletal muscle, but more importantly they appear to be the ones most responsible for the direct stimulation of muscle protein synthesis.
- Blood and tissue concentrations of BCAA are altered by several disease and other abnormal physiological states, including diabetes, liver dysfunction, starvation, protein/calorie malnutrition, alcoholism, and obesity.
A study conducted at the University of Texas Medical Branch at Galveston concluded the important role of leucine in the formulation of any amino acid/protein supplement for reversing a weakened response of muscle protein synthesis to nutritional supplementation in the elderly.
- Studies now indicate HMB inhibits protein degradation in the body, which promotes muscle growth, and prevents muscle breakdown.
- HMB appears to be the main metabolite of leucine that more effectively prevents the breakdown of muscle protein.
- A review article, published in January 2008 in the “Nutrition & Metabolism” journal, indicates that multiple studies found that HMB had positive effects on strength, lean body composition and reduced soreness on trained athletes.
- HMB helps speed up muscle repair and recovery time.
Numerous studies have found increases in lean muscle mass and strength in the elderly and clinical populations when using HMB. Our research section contains papers as well as a link to PubMed which can be used to look up the studies on HMB. Please read “International Society of Sports Medicine Postion on HBM.”
- Protein building block that facilitates metabolism and immune system.
- After surgery or traumatic injury, nitrogen is necessary to repair the wounds and keep the vital organs functioning. A large and critical portion of this nitrogen comes from glutamine.
- Supports human growth hormone secretion (HGH). HGH is sometimes referred to as the “youth” hormone and is a significant factor for why younger people heal more effectively.
- A very effective intestinal and immune system health compound, as these cells use glutamine as the preferred fuel source rather than glucose.
- Additionally, HGH plays a large role in fat metabolism and muscle growth.
According to NYU Lagone Medical Center “Heavy exercise, infection, surgery, and trauma can deplete the body’s glutamine reserves, particularly in muscle cells. The fact that glutamine does so many good things in the body has led people to research glutamine supplements as a treatment for various conditions, including preventing the infections that often follow endurance exercise, reducing symptoms of overtraining syndrome, improving nutrition in critical illness, alleviating allergies, and treating digestive problems. Please read Nutrition in Clinical Practice’s “Clinical applications of Glutamine”.
- Increases protein absorption and amino acid levels
- Helps break down ingested protein into individual amino acids
- Increases lean muscle mass and nitrogen retention rate
- Helps build lean muscle mass, reduce body fat, and increase metabolism.
- Clinical research has shown Aminogen® to increase BCAA retention levels by 250%, nitrogen levels in muscle by 32% and overall amino acid plasma levels by 100%
The Laboratory of Nutrition and Nutritional Biochemistry, University of Yaounde I, Cameroon, conducted a clinical study on Aminogen. This study tracked the increases in protein absorption, nitrogen retention, and blood CRP reduction in subjects who were first given a protein supplement without Aminogen, and then later given a protein supplement with Aminogen.
Two groups of healthy males were assigned a specific balanced diet during all legs of the study. Each subject was dosed with 50 grams of whey protein concentrate (WPC) following an overnight fast. Nine days later the groups were again dosed with 50 grams of WPC following an overnight fast, but this time the protein contained 2.5g of Aminogen for one group or 5g of Aminogen for the other
The study found that almost all individual amino acid blood levels, excluding glycine, histidine, methionine, and serine, were significantly higher in the second dosing compared to the first. Nitrogen levels were also much higher and CRP levels were reduced.
The study was published in the Journal of the International Society of Sports Nutrition.
A 2008 study published in the Journal of the International Society of Sports Nutrition found that adding Aminogen digestive enzyme system to whey protein favorably impacted three important factors related to aging metabolism: the product helped to triple the rate of protein absorption, increase branched‐chain amino acid absorption by 250% and increased nitrogen retention by 32%.
- Increases the body’s BMR or basal metabolic rate.
- Lowers elevated total serum cholesterol levels.
- Increases HDL (“good”) cholesterol levels
- MCTs have been shown to enhance thermogenesis (i.e., fat burning)
- Increase energy levels and enhance physical endurance.
- Increase fatty acid metabolism to aid in reducing fat deposits.
- Enhanced absorption of calcium, magnesium and amino acids also appears to be improved.
- Prevents the breakdown of proteins (catabolism) post-exercise.
- A useful addition to the diet of those suffering from any form of malnutrition, tissue wasting, following surgery or during recovery from severe injuries, burns and infections.
Age related muscle loss is often accompanied by increased levels of body fat and a reduction in metabolism. MCT’s have been shown to reduce body fat deposits while increasing basal metabolic rate.
In one 16-week study, 31 overweight patients consumed either olive oil or MCT oil in muffins. All of the subjects participated in dietitian-led weekly group weight-loss counseling sessions that stressed following a prudent diet, and encouraged healthy eating patterns. The oils accounted for roughly 12 percent of participants’ calorie prescription.
At 16 weeks, the MCT group had lost significantly more weight: an average of 7 pounds, or 3.8 percent of their baseline body weight, compared with 1.7 percent in the olive oil group…an over 200% improvement and over twice the total weight loss of the control group. The MCT group also had a 1.5 percent decrease in total fat mass as measured by CT scan, including a reduction in intra-abdominal fat.
- Increased calcium and mineral absorption in the body
- Decreased levels of serum cholesterol
- Ideal for maintaining mineral density and bone strength
- Aids in support immunity
- Supports the growth and balance of important bacteria in the digestive track.
The gut microbiota is the population of bacteria and other microbes that live in your gut. This community is highly complex, and contains both good and bad bacteria. Having the right balance of bacteria is essential for keeping your gut healthy and protecting you from disease.
Fructooligosaccharides can help promote this balance. In fact, studies have shown that FOS can help stimulate the growth of beneficial bacteria. Increasing the amounts of these bacteria can help improve digestion, immunity and overall health.
In addition, to their prebiotic benefits, Fructooligosaccharides also increase calcium absorption in the body, an important consideration for pre- and post-menopausal women, ages 45 and older, who are losing critical bone mass that increases their risk for osteoporosis and bone fractures.
- Maintains the health of arteries and prevent cardiovascular disease
- May also help to regulate blood pressure
- Improves muscle mitochondrial fatty acid utilization and metabolism
- Confers resistance against oxidative stress, injury and cell death
- Alters metabolism and inhibits protein catabolism
Research findings provide evidence for the modest but potentially important benefits of resveratrol supplementation in improving skeletal muscle regeneration following a period of disuse with a subsequent recovery in aging. Resveratrol has been shown to alter metabolism, inhibit protein catabolism, improve function, and provides resistance against oxidative cellular stress, injury, and cell death of skeletal muscle cells. This is particularly relevant in the elderly population which experience preferential atrophy of type II fibers in sarcopenia.
- Boosts metabolism and helps burn fat
- Prevents oxidative stress
- Helps lower total & LDL cholesterol
- Raises HDL cholesterol
- Helps reduce inflammation
- Slows breakdown of cartilage
Population-based studies and clinical trials have shown that green tea is beneficial to human health. Laboratory studies have also shown that green tea may help protect against loss of brain cells, bacterial and viral infections, allergies, arthritis and decreased bone mineral density, among other health concerns. A clinical trial in human volunteers has also revealed that green tea also helps improve immunity and prevents cold and flu symptoms in its participants.
- May help to protect against cardiovascular disease
- Supports healthy blood pressure
- Supports cellular health
- Supports arterial health
- Provides a noticeable energy boost
- Present in high concentrations in bone remodeling
CoQ10 is needed in the mitochondria of your body’s cells to make the storage form of energy called adenosine triphosphate, or ATP. Raising a low CoQ10 level could benefit problems with energy production in tissues such as heart or muscle, and increasing your CoQ10 intake may improve your exercise capacity and endurance.
- Relieves symptoms of chronic venous insufficiency
- Contains antioxidants
- Helps prevent oxidative stress
- Helps lower low density lipids (LDL)
- Helps improve circulation
- Demonstrates evidence of anti-inflammatory properties
- Helps prevent muscle wasting
A study of healthy volunteers found that taking grape seed extract substantially increased blood levels of antioxidants. Antioxidants are substances that destroy free radicals, which are harmful compounds in the body that damage DNA (genetic material) and even cause cell death. Scientists believe free radicals contribute to aging, as well as the development of a number of health problems, including heart disease and cancer. Another study found that people who took grape seed extract after experiencing a sports injury had less swelling than those who took a placebo.
- Increased strength
- Increased muscle mass
- Improved energy
- Improved muscle firmness
- Improved sense of well being
- Combats age related muscle loss
- Supports cellular energy
In a study examining creatine’s effect on isometric strength and body composition, 28 healthy men and women over the age of 65 received either five grams of creatine daily or a placebo. In this random, double-blind study, both the creatine and placebo groups were put on a resistance (weight) training regimen. Fourteen weeks of training resulted in significant increases in all measurements of strength, functional tasks, and muscle fiber area in both groups.
However, the creatine group experienced significantly greater increases in fat-free muscle mass, knee extension strength, ankle strength and intramuscular creatine levels. The researchers concluded that the addition of creatine supplementation to the exercise stimulus enhanced the increase in total fat-free mass and gains in several indices of participant muscle strength.
- Supplements to Support Of Existence Exercise to Combat Sarcopenia
- Strategic Creatine Supplementation In Elderly
- Meta Analysis of Creatine Supplemenation in Older Adults
- Effects of Combined Creatine and Sodium Bicarbonate
- Creatine Supplementation in Aging Population
- Creatine Supplementation and Resistance Training in Older Women
- Vitamin A is required for epithelial and bone formation, cellular differentiation and immune function. It therefore plays a significant role in wound healing and bone healing/rebuilding.
- Most cartenoid forms of vitamin A function as antioxidant and anti-inflammatory nutrients.
According to National Institute of Health: “Vitamin A is essential for good health. It promotes growth, the immune system, reproduction, and vision. However, recent research suggests that too much vitamin A, particularly in the form of retinol, may be bad for your bones.” Please refer to the NIH Osteoporosis and Related Bone Diseases site for more information on studies and recommended intake.
- B1 (Thiamin) – Assists with digestion, maintains the proper stomach acid level, converts carbohydrates into energy, and helps stabilize the nervous system.
- B2 (Riboflavin) – Aids with ensuring healthy skin, good eyesight, and the use of carbohydrates, proteins and fats for energy.
- B3 (Niacin) – Promotes good circulation, decreases high blood pressure, assists with digestive system function, maintains sharp cognitive abilities and captures energy from food.
- B5 (Panthothenic Acid) – Maintains healthy adrenal glands, assists with the growth of antibodies and converts food into energy.
- B6 (Pyridoxal Phosphate) – Achieves the proper balance of fluids in the body, increases protein metabolism, and promotes the formation of red blood cells.
- B7 (Biotin) – Enhances the health of hair and skin and ramps up the metabolism of fat, proteins and carbohydrates.
- B9 (Folic acid) – Aids with the generation and reproduction of red blood cells
- B12 (Cobalamin) – Enhances the growth of red blood cells and helps stabilize the nervous system
Below is a list of all the different ways that B complex vitamins support the human body:
B-Complex allows for supplementation of all eight vitamins simultaneously, as multiple deficiencies can overload the body with a number of illnesses and ailments. The B-Complex vitamin is a powerhouse of a vitamin combination as all of these separate vitamins work hand in hand to deliver powerful health benefits to the body. These health benefits provided by the B-complex vitamin include support of the metabolism and increase in the rate of metabolism, maintenance of healthy muscle tone and skin and enhancing the function of the nervous system and the immune system.
- Known as a strong antioxidant, vitamin C can help neutralize the free radicals associated with trauma and injury.
- Aids in building connective tissue.
- Aids in wound healing.
ccording to PubMed: “Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA).” According to another study on Vitamin C as an antioxidant: “Vitamin C in humans must be ingested for survival. Vitamin C is an electron donor, and this property accounts for all its known functions. As an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Antioxidant effects of vitamin C have been demonstrated in many experiments in vitro.” According to Dr. Sinatra: Because surgery depletes your body of vitamin C, take 500–1,000 mg as part of your daily routine before surgery and 1,000 mg three times a day after surgery. Return to your usual dosage after two weeks. Numerous studies indicate that vitamin C helps prevent surgical shock and post-surgical bed sores, and that it significantly speeds healing time. It’s also necessary for the production of collagen—a basic structural protein used in wound repair.
- Crucial for absorption of calcium and bone health. The Vitamin D will help aid the absorption of the Calcium contained in MEND.
- Aids and regulates the immune system.
Vitamin D has become one of the most researched and prescribed vitamins. Conclusions according to one study: “This meta-analysis supports the use of vitamin D3 of 800 IU daily to reduce the incidence of osteoporotic non-vertebral, hip, and non-vertebral-non-hip fractures in elderly women. Vitamin D(3) with calcium appears to achieve benefits above those attained with calcium supplementation alone for non-vertebral and non-vertebral-non-hip fractures.”
- An essential nutrient to build, maintain and restore bones during the healing process.
- Recent studies show that a flash of calcium is the body’s first immune response to healing tissue.
- Plays a critical role in nerve function, muscle movement and to carrying messages from the brain to the rest of the body, all of which are critical for the healing process.
- Helps move blood throughout the body and to help release important hormones and enzymes, important in the healing process.
The findings of a 2013 study, published in Current Biology, shows that a flash of calcium is the body’s first response to healing damaged tissue. According to Medscape: “Calcium plus vitamin D supplements are routinely prescribed for the prevention of osteoporosis and fracture. Although a major study from 2006 questioned this practice, a new meta-analysis reaffirms the usefulness of calcium plus vitamin D in the prevention of fracture.”
- Improves sleep
- Relaxes the nervous system
- Improves muscle function
- Supports protein synthesis
- Allows the body to produce more Insulin-like Growth Factor (IGF-1)
- Helps control stress hormones
- Helps relax tight muscles and improve flexibility
- Supports bone integrity and strength
- Alkalizes the body
- Essential for proper hydration.
- Helps to relieve constipation
- Assists enzyme function
Older age is frequently characterized by sarcopenia, a loss of skeletal muscle mass and function that is a strong independent risk factor for disability and mortality. Recent data show that inadequate magnesium intake is common, especially in older persons. Because magnesium status is strictly related to muscle ATP, and because both magnesium deficiency and sarcopenia tend to be more prevalent at older ages, it was hypothesized that poor magnesium status contributes to late-life sarcopenia.
The results of the study show an independent concurrent relation between serum magnesium and muscle performance in a large cohort of community-resident older persons. A possible mechanism of this association is the effect of magnesium concentrations on mitochondrial function in muscle, which may be particularly critical in aging muscle.
- Supports brain and cognitive function
- Stabilizes blood sugar
- Helps maintain optimal muscle and nerve function
- Helps prevent muscle cramps
- Supports mineral density of bones
- Helps regulate blood pressure
- Helps muscle growth and strength
- Supports protien synthesis
- Rehydrates and optimizes fluid balance
Potassium is a very important mineral for the proper function of all cells, tissues, and organs in the human body. Studies have shown a positive link between a diet rich in potassium and bone health, particularly among elderly women, suggesting that potassium may play a role in preventing osteoporosis. There is also some evidence that potassium supplements may cause a slight drop in blood pressure.
- Support the immune system
- Support heart health
- Precursor to glutathione
- Supports thyroid function
- Reduces inflammation
Clinical studies on the use of selenium were searched for in the PubMed electronic database. Sixteen clinical studies were identified among the 167 articles selected in the initial search. The studies were conducted worldwide including European, American and Asian countries between 1987 and 2012.. Selenium supplementation improved the general conditions of the patients while improving the quality of life and reducing the side effects of those who received radiotherapy.
- Helps balance pH levels
- Relieves heartburn and indegestion
- Reduces stomach acid
- Buffers lactic acid build up
- Delays fatigue and enhances athletic performance.
Where can I buy MEND Regenerate?
MEND Regenerate is available from your Orthopedic Surgeon or Doctor and can be purchased directly from our website.
Can you ship to my country?
Yes, MEND is shipped worldwide. Please be aware of your country’s policy for importing dietary supplements and that additional taxes and tariffs may be applied by your country.
What flavors are available?
Currently available in chocolate/cocoa and vanilla. The vanilla version is NSF Sport certified to allow for use in professional sports and therefore is a little more expensive. We will be adding flavors.
Is it safe to use with my medications?
MEND Regenerate contains only well-studied nutrients that are well tolerated. It is always advisable to consult with your doctor before taking any dietary supplements.†
Is MEND proven to work?
All of the nutrients in MEND Regenerate were selected based on the science and evidence supporting their efficacy. We now have years of patient and client data and testimonials suggesting that when used in conjunction with resistance training and exercise, MEND Regenerate will provide multiple benefits.†
How is MEND Regenerate taken?
We recommend that you blend MEND Regenerate into a smoothie to help aid absorption of nutrients. There are a number of smoothie recipes provided on our website.
Are you looking for partners?
Yes we are looking to partner with physicians and other healthcare providers. Please email us at firstname.lastname@example.org for more information.